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Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial
Zahra Azadbakht1, Firozeh Sajedi2, Mohammad Mahdi Mahboobian3
1Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Objectives:
The aim of this study was to recognize the efficacy and safety of curcumin ointment on patients with knee osteoarthritis (OA) compare to diclofenac as standard medication.
Methods:
The topical effects of curcumin (10%) and diclofenac (1%) ointments were assessed through the visual analog scale (VAS) and Western Ontario and McMaster Universities Arthritis (WOMAC) index after three times a day administration for two weeks in 60 patients.
Results:
Desirable effects compared to the pre-treatment period were observed after two weeks of continuous treatment. Based on our results, VAS and WOMAC index were altered after treatment significantly (p<0.0001).
Conclusions:
Two-week use of curcumin ointment could ameliorate the pain, stiffness and function disability in patients with OA.
