Related Experiment Video
Updated: Oct 4, 2025

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Menopause and female sexual dysfunctions
Laura Cucinella1,2, Ellis Martini3, Lara Tiranini3,4
1Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS S. Matteo Foundation, Pavia, Italy - laura.cucinella01@universitadipavia.it.
Female sexual dysfunctions (FSDs) in menopausal women stem equally from biological and psycho-relational factors. Addressing sexual health proactively during midlife consultations is crucial for diagnosis and effective treatment.
Area of Science:
- Reproductive Medicine
- Psychology
- Gerontology
Background:
- Female sexual dysfunction (FSD) is prevalent in menopausal women, influenced by biological and psychosocial elements.
- Midlife consultations are opportune moments for healthcare providers to proactively address sexual health concerns.
- Patients often do not spontaneously report sexual symptoms, necessitating direct inquiry.
Purpose of the Study:
- To highlight the equal contribution of biological and psycho-relational factors in FSD development.
- To emphasize the importance of a proactive approach by healthcare providers in midlife sexual health discussions.
- To underscore the necessity of a comprehensive sexual history for accurate diagnosis and management.
Main Methods:
- Review of contributing factors to sexual symptoms and distress in menopausal women.
- Analysis of the role of midlife consultations in identifying FSDs.
- Emphasis on detailed sexual history taking to characterize symptoms and identify contributing factors.
- Discussion of common FSDs at midlife, including hypoactive sexual desire disorder and genitourinary syndrome of menopause.
Main Results:
- Both biological and psycho-relational factors are equally significant in FSD development and associated distress.
- Hypoactive sexual desire disorder and genitourinary syndrome of menopause are frequent FSDs in midlife.
- A multidimensional approach is essential for effective management.
Conclusions:
- Accurate sexual history taking is vital for diagnosing FSDs and understanding their impact.
- Management requires a multidimensional strategy, including patient education, risk factor modification, and tailored non-pharmacological and pharmacological treatments.
- Addressing both biological and psychosocial components is key to managing FSDs in menopausal women.
Related Concept Videos
Menopause
Disorders of the Female Reproductive System
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
Menses Phase
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
Signs of Puberty

