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Microfluidics and surface-enhanced Raman spectroscopy, a win-win combination?

Rajapandiyan Panneerselvam^1,2, Hasan Sadat¹, Eva-Maria Höhn¹

¹Institute of Analytical Chemistry, Leipzig University, Linnéstraße 3, 04103 Leipzig, Germany.

|February 2, 2022

Summary

Microfluidic surface-enhanced Raman spectroscopy (MF-SERS) enhances analytical chemistry by improving the sensitivity and reproducibility of SERS measurements for ultra-low concentration analytes. This review explores MF-SERS substrates and platforms, highlighting its potential to overcome SERS limitations.

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Area of Science:

Analytical Chemistry
Nanoscience and Nanotechnology
Spectroscopy

Background:

Surface-enhanced Raman spectroscopy (SERS) provides structural and chemical information for ultra-low concentration analytes.
Key challenges in SERS include measurement reproducibility and sensitivity, particularly for small molecules.
Microfluidic integration offers a promising solution to enhance SERS performance.

Purpose of the Study:

To review the advancements and potential of microfluidic surface-enhanced Raman spectroscopy (MF-SERS) as a powerful analytical tool.
To discuss the development of SERS substrates within microfluidic devices.
To explore microfluidic platform materials and types relevant to MF-SERS.

Main Methods:

Critical review of SERS substrates designed for microfluidic applications.
Analysis of how microfluidic channels improve SERS sensitivity, reproducibility, and detection limits.
Examination of materials and types of microfluidic platforms (droplet, centrifugal, digital).

Main Results:

Microfluidic integration significantly enhances SERS sensitivity, reproducibility, and detection limits.
Specific SERS substrates and microfluidic designs are crucial for optimal performance.
Various microfluidic platforms demonstrate suitability for MF-SERS applications.

Conclusions:

MF-SERS effectively addresses inherent limitations of traditional SERS techniques.
The integration of SERS with microfluidics offers a versatile and powerful analytical approach.
Future research directions and challenges in MF-SERS are identified.