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Childhood Hypertriglyceridemia: Is It Time for a New Approach?
Bhuvana Sunil1, Ambika P Ashraf2
1Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Mary Bridge Children's Hospital, Tacoma, WA, USA.
Current Atherosclerosis Reports
|February 2, 2022
Summary
Hypertriglyceridemia (HTG) in youth requires effective treatments. Emerging therapies target specific pathways to manage triglyceride levels and reduce risks of pancreatitis and cardiovascular disease.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Disease Prevention
- Metabolic Disorders
Background:
- Hypertriglyceridemia (HTG) is common in children and adolescents.
- Elevated triglycerides (TG) increase risks for pancreatitis and premature atherosclerotic cardiovascular disease (ASCVD).
- Non-alcoholic fatty liver disease is increasingly linked to HTG in youth.
Purpose of the Study:
- To review current management strategies for HTG in acute and chronic settings in youth.
- To highlight novel therapeutic approaches targeting specific genes, proteins, and enzymes.
- To discuss the role of lifestyle modifications and emerging pharmacological interventions.
Main Methods:
- Literature review of studies on HTG management in pediatric populations.
- Analysis of current and emerging pharmacological treatments.
- Synthesis of evidence on lifestyle interventions and their impact.
Main Results:
- Lifestyle changes are foundational for HTG management in youth.
- Pharmacological options include fibrates, omega-3 fatty acids, and statins for moderate-to-severe HTG.
- Newer therapies targeting apolipoprotein C3 and angiopoietin-like protein 3 show promise.
Conclusions:
- Management of HTG in youth should be tailored to etiology, symptoms, and TG levels.
- Non-high-density-lipoprotein-cholesterol (non-HDL-C) is a key therapeutic target.
- Targeted therapies offer new avenues for managing pediatric HTG and associated ASCVD risks.
Keywords:
AtherosclerosisCholesterolChylomicronemiaPancreatitisPediatric hypertriglyceridemiaTherapeuticsMore Related Videos
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