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Handheld Platform for Sensitive Rosiglitazone Detection: Immunosensor Based on a Time-Based Readout Device.

Hongzhi Liang1, Aori Qileng1,2, Haoran Shen1

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Analytical Chemistry
|February 2, 2022
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Summary
This summary is machine-generated.

A new smartphone-controlled device enables rapid, on-site detection of rosiglitazone (RSG) in food. This portable immunoassay offers sensitive and selective monitoring for food safety, preventing adverse health effects from excessive intake.

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Area of Science:

  • Analytical Chemistry
  • Biosensors
  • Food Safety

Background:

  • Excessive rosiglitazone (RSG) intake poses health risks.
  • Current detection methods (LC-MS, GC-MS) lack portability for on-site analysis.
  • Need for rapid, sensitive, and selective methods for RSG detection in food.

Purpose of the Study:

  • Develop a portable time-based readout (TBR) device for rosiglitazone (RSG) immunoassay.
  • Integrate the TBR device with smartphone application (APP) for user-friendly operation.
  • Enable sensitive and selective detection of RSG for point-of-care food safety monitoring.

Main Methods:

  • Fabricated a two-electrode system TBR device: glassy carbon bioanode and Prussian blue-modified FTO cathode.
  • Utilized Au-modified octahedral Cu2O as mimetic peroxidase for signal amplification.
  • Employed 4-chloro-1-naphthol (4-CN) catalysis to generate an insulating layer and electrochromic changes.
  • Developed a smartphone APP to recognize time-to-potential and chroma value variations.

Main Results:

  • Achieved sensitive and selective immunoassay for RSG detection.
  • Demonstrated linear responses for the square root of time and chroma value within the range of 5 × 10^-10 to 5 × 10^-7 g/L.
  • Obtained low limits of detection: 8.2 × 10^-11 g/L (time-based) and 1.3 × 10^-10 g/L (chroma-based).
  • The TBR device showed indirect correlation between RSG concentration and time to reach a fixed potential.

Conclusions:

  • The developed TBR device with APP offers a sensitive, selective, and portable solution for RSG detection.
  • Promising for point-of-care monitoring of hazardous materials in food and environmental samples.
  • Facilitates rapid risk assessment and ensures food safety compliance.