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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the

Fabio Begnini1, Stefan Geschwindner2, Patrik Johansson2

  • 1Department of Chemistry─BMC, Uppsala University, Box 576, 75123 Uppsala, Sweden.

Journal of Medicinal Chemistry
|February 2, 2022
PubMed

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