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Updated: Oct 4, 2025
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Technetium(I) Carbonyl Chemistry with Small Inorganic Ligands
Maximilian Roca Jungfer1, Laura Elsholz1, Ulrich Abram1
1Institute of Chemistry and Biochemistry, Freie Universität Berlin, Fabeckstraße 34/36, D-14195 Berlin, Germany.
Abstract:
[Tc(OH2)(CO)3(PPh3)2](BF4) has been used as a synthon for reactions with small inorganic ligands with relevance for the treatment of nuclear waste solutions such as nitrate, nitrite, pseudohalides, permetalates (M = Mn, Tc, Re), and BH4-. The formation of bond isomers and/or a distinct reactivity has been observed for most of the products. [Tc(NCO)(CO)3(PPh3)2], [Tc(NCS)(CO)3(PPh3)2], [Tc(CN)(CO)3(PPh3)2], [Tc(N3)(CO)3(PPh3)2], [Tc(NCO)(OH2)(CO)2(PPh3)2], [Tc(η2-OON)(CO)2(PPh3)2], [Tc(η1-NO2)(CO)3(PPh3)2], [Tc(η2-OONO)(CO)2(PPh3)2], [Tc(η1-ONO2)(CO)3(PPh3)2], [Tc(η2-OO(CCH3))(CO)2(PPh3)2], [Tc(η2-SSC(SCH3))(CO)2(PPh3)2], [Tc(η2-SSC(OCH3))(CO)2(PPh3)2], [Tc(η2-SSC(CH3))(CO)2(PPh3)2], [Tc(η2-SS(CH))(CO)2(PPh3)2], [Tc(OTcO3)(acetone)(CO)2(PPh3)2], [Tc(OTcO3)(CO)3(PPh3)2], and [Tc(η2-HHBH2)(CO)2(PPh3)2] have been isolated in crystalline form and studied by X-ray crystallography. Additionally, the typical reactivity patterns (isomerization, thermal decomposition, hydrolysis, or decarbonylation) of the products have been studied by spectroscopic methods. 99Tc NMR spectroscopy has proved to be a particularly useful tool for the evaluation of such reactions of the diamagnetic technetium(I) compounds in solution.
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