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Association between Insulin Resistance and Cognitive Impairment
Mingyue Chen1, Min Zhang1, Shenglin Wang1
1Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Institute of Neurological Diseases, North Sichuan Medical College, Nanchong, Sichuan, China.
Insulin resistance is linked to cognitive impairment, with a notable negative association found in this systematic review. This suggests insulin resistance may play a role in cognitive decline and conditions like Alzheimer's disease.
Area of Science:
- Endocrinology and Neurology
- Metabolic Syndrome Research
Background:
- Insulin resistance is a metabolic condition associated with type 2 diabetes.
- Cognitive impairment encompasses deficits in memory, attention, and executive function.
- Emerging evidence suggests a link between metabolic health and brain function.
Purpose of the Study:
- To systematically review and meta-analyze the relationship between insulin resistance and cognitive impairment.
- To determine if insulin resistance is a significant factor in the development of cognitive deficits.
Main Methods:
- A comprehensive literature search was conducted across Medline, Embase, Web of Science, and Cochrane Library.
- Two independent reviewers selected studies and extracted data, assessing quality using the Newcastle-Ottawa Scale.
- A random-effects model meta-analysis was performed on data from eight included articles (1,399 subjects).
Main Results:
- A statistically significant negative association was found between insulin resistance and cognitive function (R = -0.262; 95% CI: -0.309 to -0.215).
- The meta-analysis included eight studies with a total of 1,399 participants.
- Higher levels of insulin resistance correlated with poorer cognitive performance.
Conclusions:
- Insulin resistance is significantly associated with cognitive impairment.
- The findings support the hypothesis that insulin resistance may be a contributing mechanism to cognitive decline.
- Further research into metabolic interventions for cognitive health is warranted, particularly concerning Alzheimer's disease.
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