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Cell cycles in cell hierarchies.

C S Potten

    International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Stem cells in renewing tissues like bone marrow and testis have longer cell cycles than transit cells. This hierarchical organization ensures efficient tissue regeneration and cell replacement.

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    Area of Science:

    • Cell biology
    • Tissue regeneration
    • Stem cell research

    Background:

    • Cell replacement is crucial for maintaining tissue function in various organs.
    • Hierarchical proliferative compartments with stem and transit cells are common in renewing tissues.

    Purpose of the Study:

    • To investigate the cell cycle dynamics of stem cells versus transit cells in renewing tissues.
    • To understand the role of cell cycle length in hierarchical tissue organization.

    Main Methods:

    • Comparative analysis of cell cycle times in different tissue compartments.
    • Review of existing experimental evidence on cell proliferation in bone marrow, testis, and epithelia.

    Main Results:

    • Stem cells generally exhibit longer cell cycle times compared to transit cells.

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  • Cell cycle lengthening is observed as cells progress towards more primitive states in tissues like the small intestine and testis.
  • Variations in cell cycle dynamics exist across different tissues and cell types.

    • Conclusions:

    • The hierarchical organization of proliferative compartments, with distinct stem and transit cell populations, is a key mechanism for tissue renewal.
    • Differences in cell cycle times between stem and transit cells contribute to the regulation of tissue homeostasis and regeneration.