Related Experiment Video

Updated: Oct 4, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
10:33

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

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Loss of TET2 Tips the Scales Toward Tumorigenesis

Brian C Capell1

  • 1Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

The Journal of Investigative Dermatology
|February 3, 2022
PubMed

Insights

Ten-eleven translocation (TET) enzymes regulate DNA methylation, crucial for cell differentiation and cancer prevention. This study reveals TET2

Area of Science:

  • Epigenetics
  • Dermatology
  • Cancer Biology

Background:

  • DNA methylation is vital for cellular differentiation and cancer.
  • DNA methyltransferases are well-studied in skin biology.
  • Ten-eleven translocation (TET) demethylase roles remain unclear in epidermal biology.

Purpose of the Study:

  • Investigate the function of TET demethylase enzymes in skin.
  • Determine the role of TET2 in squamous cell carcinoma (SCC) development.
  • Elucidate the regulation of 5-hydroxymethylcytosine by TET2 in SCC prevention.

Main Methods:

  • Analysis of TET2 expression and function in epidermal models.
  • Assessment of 5-hydroxymethylcytosine levels in relation to TET2 activity.
  • Evaluation of TET2's impact on squamous cell carcinoma development.

Main Results:

  • TET2 plays a significant role in regulating 5-hydroxymethylcytosine.
  • Evidence suggests a tumor-suppressive function for TET2 in the epidermis.
  • TET2 activity is linked to the prevention of squamous cell carcinomas.

Conclusions:

  • TET2 is a key regulator in preventing squamous cell carcinomas.
  • Understanding TET2's epigenetic role offers new avenues for cancer prevention strategies.
  • Further research into TET demethylases is warranted for skin cancer biology.

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