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The association between elevated lipid profile and liver enzymes: a study on Bangladeshi adults
Rahanuma Raihanu Kathak1, Abu Hasan Sumon1, Noyan Hossain Molla1
1Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
Insights
This study found high rates of dyslipidemia (abnormal blood lipids) and elevated liver enzymes in Bangladeshi adults. Gamma-glutamyl transferase (GGT) levels were independently linked to all lipid components, suggesting a connection between lipid disorders and liver health.
Area of Science:
- Cardiology
- Hepatology
- Clinical Biochemistry
Background:
- Dyslipidemia is a growing concern in Asia, linked to cardiovascular, renal, and hepatic complications.
- Data on dyslipidemia and its association with liver enzymes in Bangladesh is limited.
- Understanding these relationships is crucial for public health in the region.
Purpose of the Study:
- To determine the prevalence of dyslipidemia in Bangladeshi adults.
- To investigate the relationship between lipid profiles and liver enzymes.
- To assess the association between dyslipidemia and liver enzyme abnormalities.
Main Methods:
- A cross-sectional study involving 405 Bangladeshi adults.
- Serum lipid profiles (TG, TC, LDL, HDL) and liver enzymes (ALT, AST, GGT, ALP) were analyzed.
- Logistic regression was used to assess associations.
Main Results:
- High prevalence of dyslipidemia (elevated TG, TC, LDL; low HDL) and elevated liver enzymes (ALT, AST, GGT, ALP) were observed.
- Dyslipidemia and liver enzyme abnormalities were more common in participants with diabetes and hypertension.
- 61% of participants with dyslipidemia had at least one elevated liver enzyme.
- Serum GGT showed an independent association with all lipid components.
Conclusions:
- A significant prevalence of dyslipidemia and liver enzyme abnormalities exists in the Bangladeshi population.
- Serum GGT is independently associated with all measured lipid components.
- Dyslipidemia may increase the risk of liver disease in this population, warranting further investigation.
Abstract:
Dyslipidemia, a major contributor to cardiovascular diseases, is rapidly increasing in Asian countries including Bangladesh. In addition to the cardiovascular system, abnormal lipid levels are also known to cause complications in renal and hepatic systems. The data regarding dyslipidemia and its relationship with liver enzymes are scarce for the Bangladeshi population. Therefore, this study was conducted to estimate the prevalence of dyslipidemia and determine the relationship between lipid profile and liver enzymes in Bangladeshi adults. A total of 405 participants (318 males and 87 females) were enrolled in the study. Serum levels of TG, TC, LDL, HDL and liver enzymes including ALT, AST, GGT and ALP were analyzed using standard methods. Dyslipidemia and liver function tests abnormalities were defined according to the international standard guidelines. The association between elevated lipid profile markers and liver enzyme abnormalities was assessed by logistic regression analysis. Overall, the prevalence of elevated TG, TC, LDL and low HDL were 30.9%, 23.7%, 26.2% and 78.8%, respectively. On the other hand, the prevalence of elevated liver enzymes ALT, AST, GGT and ALP were 18.8%, 21.6%, 12.9% and 21.9%, respectively. Dyslipidemia and liver enzyme abnormalities were higher in diabetic and hypertensive participants than in the healthy participants. About 61% of participants with dyslipidemia had at least one or more elevated liver enzymes. In regression analysis, an independent association was observed between serum GGT and all lipid components. In conclusion, a high prevalence of dyslipidemia and liver enzyme abnormalities were observed among the study participants. Of the four liver enzymes, the serum levels of GGT showed an independent association with all lipid components. Moreover, this study indicates that subjects with dyslipidemia often have a higher chance of having liver diseases than subjects with no dyslipidemia. However, large-scale prospective studies are needed to understand the underlying mechanisms of lipid-induced hepatic dysfunction in the Bangladeshi population.
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