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Updated: Oct 4, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Acute Herpes Simplex Esophagitis in an Immunocompetent Adult with Eosinophilic Esophagitis
Thomas Adam Wichelmann1, Ryan T Hoff2, Dean N Silas2
1Division of Internal Medicine, Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Illinois, USA.
Abstract:
Herpes simplex esophagitis (HSE) represents a rare entity in immunocompetent patients and has infrequently been described in association with eosinophilic esophagitis (EoE). Causality in this rare association remains a debated topic. We present a case of HSE occurring in an immunocompetent adult with EoE and review the literature in support of EoE induced mucosal disruption predisposing to increased risk of HSE.
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