Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental scleroma. A histopathological study.

M Talaat, A Soliman, H Gaafar

    The Journal of Laryngology and Otology
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids.

    Nature communications·2026
    Same author

    Cyber-resilient machine learning framework for accurate individual load forecasting and anomaly detection in smart grids.

    Scientific reports·2025
    Same author

    Numerical investigation of high-temperature proton exchange membrane fuel cell conductivity at different parameters.

    Scientific reports·2025
    Same author

    Patient Experiences of Using Wearable Health Monitors During Cancer Treatment: A Qualitative Study.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2024
    Same author

    A Clinically Explainable AI-Based Grading System for Age-Related Macular Degeneration Using Optical Coherence Tomography.

    IEEE journal of biomedical and health informatics·2024
    Same author

    Effect of dapagliflozin against NAFLD and dyslipidemia in type 2 diabetic albino rats: possible underlying mechanisms.

    European review for medical and pharmacological sciences·2023
    Same journal

    Discomfort and Intolerance During 24-Hour Multichannel Intraluminal Impedance-pH Monitoring.

    The Journal of laryngology and otology·2026
    Same journal

    The Effect of Hand Dominance on Results in the Functional Head Impulse Test.

    The Journal of laryngology and otology·2026
    Same journal

    Prognostic value of gross tumour volume in laryngeal cancer: a systematic review and meta-analysis.

    The Journal of laryngology and otology·2026
    Same journal

    Surgical Management Of Parapharyngeal Vagal Schwannomas: A Systematic Review And Practical Considerations For Approach Selection.

    The Journal of laryngology and otology·2026
    Same journal

    Novel Use of Lieberman Self-Retainers for Nasal Alar Retraction.

    The Journal of laryngology and otology·2026
    Same journal

    Prevalence and recovery of taste dysfunction after stapedectomy in otosclerosis: a clinical study of 320 patients.

    The Journal of laryngology and otology·2026
    See all related articles

    Klebsiella rhinoscleromatis infection in rabbits caused lung inflammation and granulomas resembling Mikulic cells. This animal model may help understand human scleroma development.

    Area of Science:

    • Microbiology
    • Pathology
    • Veterinary Medicine

    Background:

    • Scleroma is a chronic granulomatous disease affecting the upper respiratory tract.
    • The specific pathogenesis of scleroma, particularly the role of Klebsiella rhinoscleromatis, requires further elucidation.
    • Animal models are crucial for studying infectious diseases and their pathological mechanisms.

    Purpose of the Study:

    • To investigate the pathological effects of Klebsiella rhinoscleromatis inoculation in a rabbit model.
    • To evaluate the development of granulomatous reactions in the respiratory tract following experimental infection.
    • To assess the potential of this model for understanding scleroma aetiopathogenesis.

    Main Methods:

    • Experimental inoculation of Klebsiella rhinoscleromatis into the nasal passages and maxillary sinuses of rabbits.

    Related Experiment Videos

  • Histopathological examination of respiratory tissues at various post-inoculation intervals (up to five months).
  • Comparison with control animals to identify infection-induced changes.

    • Main Results:

    • Consistent pulmonary peribronchial and perivascular granulomatous reactions were observed in all inoculated rabbits.
    • These granulomas exhibited a Mikulic cell-like appearance.
    • The severity of the observed reaction increased with prolonged survival periods.

    Conclusions:

    • The rabbit model successfully replicated key pathological features of scleroma, including granuloma formation.
    • Findings suggest Klebsiella rhinoscleromatis can induce a significant inflammatory response in the respiratory tract.
    • This experimental model provides valuable insights into the aetiopathogenesis of human scleroma.