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A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
Clinical Characteristics and Death Risk Factors of Severe Sepsis in Children
Ying Zhang1, Buqing Cao2, Weihong Cao3
1Department of Neonatology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, China.
Insights
Severe sepsis in children is a critical condition with rapid progression. Key indicators like serum lactic acid, PCIS, and organ involvement significantly impact mortality in pediatric intensive care unit patients.
Area of Science:
- Pediatric critical care medicine
- Infectious diseases
- Systemic inflammatory response
Background:
- Sepsis, a systemic inflammatory response syndrome, poses a significant threat to children, often leading to severe outcomes and high mortality rates in pediatric intensive care units (PICUs).
- Septic shock, characterized by circulatory dysfunction, presents with rapid onset and multi-organ involvement, complicating diagnosis and treatment.
- Systemic Inflammatory Response Syndrome (SIRS) contributes to approximately one million deaths globally each year, highlighting the urgent need for effective management strategies.
Purpose of the Study:
- To investigate the clinical characteristics of severe sepsis in children admitted to a PICU.
- To identify risk factors associated with mortality in pediatric severe sepsis cases.
- To analyze the relationship between specific clinical indicators and patient outcomes.
Main Methods:
- Retrospective analysis of 65 pediatric sepsis cases admitted to a PICU.
- Evaluation of clinical data, focusing on pathogenesis and treatment of septic shock.
- Assessment of serum lactic acid levels, Pediatric Index of Critical Illness Score (PCIS), and Multiple Organ Dysfunction Syndrome (MODS) as potential risk factors.
Main Results:
- The study identified significant clinical characteristics of severe sepsis in the pediatric population.
- Serum lactic acid levels, PCIS, and the extent of organ involvement in MODS were found to be interrelated.
- These factors demonstrated a notable association with the mortality rates in children suffering from severe sepsis.
Conclusions:
- Clinical indicators such as serum lactic acid, PCIS, and MODS are critical in assessing the severity and predicting outcomes in pediatric sepsis.
- Understanding these risk factors is crucial for timely intervention and improving survival rates in critically ill children.
- Further research into the interplay of these factors can refine treatment protocols for severe sepsis in pediatric patients.
Abstract:
Sepsis is a systemic inflammatory response syndrome caused by viral infection. The circulatory dysfunction caused by sepsis is also called septic shock or septic shock. The main characteristics are rapid onset, rapid changes, and involvement. Multiple organs in the body make diagnosis difficult, which seriously threatens the survival of patients. As many as one million people worldwide die every year because of SIRS, it is also the leading cause of death among children in hospital ICUs. This article is aimed at studying the clinical characteristics of severe sepsis in children and the risk factors for death. Based on the analysis of the pathogenesis of sepsis and the treatment of septic shock, 65 cases of children with PICU sepsis admitted to a hospital were selected. Data, to study its clinical characteristics and risk factors for death. The results of the study showed that despite the interaction among the removal factors of the three indexes of serum lactic acid value, PCIS level, and the number of organs involved in MODS, they are still related to the mortality of children with severe sepsis.
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