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Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

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Coagulation Disorders and Thrombosis in COVID-19 Patients and a Possible Mechanism Involving Endothelial Cells: A

An-Tian Chen1,2, Chen-Yu Wang1, Wen-Ling Zhu1

  • 11Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Aging and Disease
|February 3, 2022
PubMed

Insights

Coronavirus disease 2019 (COVID-19) significantly impacts older adults, causing coagulation disorders and thrombosis in up to 95% of patients. Endothelial cell dysfunction is a key factor in COVID-19-related clot formation and poor outcomes.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Hematology

Background:

  • Coronavirus disease 2019 (COVID-19) is a global pandemic disproportionately affecting older adults.
  • COVID-19 is associated with increased risks of organ dysfunction, mortality, and significant coagulation disorders.

Purpose of the Study:

  • To investigate the role of coagulation disorders and thrombosis in COVID-19 pathophysiology.
  • To explore the mechanisms linking endothelial cell dysfunction to hypercoagulation in COVID-19 patients.

Main Methods:

  • Review of existing literature on COVID-19, coagulation abnormalities, and endothelial cell function.
  • Analysis of laboratory findings in COVID-19 patients, including D-dimer levels, prothrombin time, and platelet counts.
  • Examination of the impact of SARS-CoV-2 on endothelial cells and related inflammatory pathways.

Main Results:

  • Up to 95% of COVID-19 patients exhibit coagulation disorders, such as elevated D-dimer and low platelet counts.
  • Thrombosis is prevalent in severe COVID-19 cases, correlating with increased mortality.
  • SARS-CoV-2 infection activates endothelial cells, leading to inflammation, dysfunction, and promoting clot formation.

Conclusions:

  • Coagulation disorders and thrombosis are critical indicators of poor prognosis in COVID-19, particularly in severe cases.
  • Endothelial cell activation and dysfunction are central to the development of hypercoagulation in COVID-19.
  • Further research is needed to fully elucidate the mechanisms of coagulopathy in COVID-19.

Keywords:
COVID-19SARS-CoV-2coagulationendothelial cellsthrombosis

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