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Updated: Oct 4, 2025

Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases
Xiaoxian Xie1, Ruonan Shu1, Chunan Yu1
11College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Abstract:
Mitochondrial dysfunction may play a crucial role in various diseases due to its roles in the regulation of energy production and cellular metabolism. Serine/threonine kinase (AKT) is a highly recognized antioxidant, immunomodulatory, anti-proliferation, and endocrine modulatory molecule. Interestingly, increasing studies have revealed that AKT can modulate mitochondria-mediated apoptosis, redox states, dynamic balance, autophagy, and metabolism. AKT thus plays multifaceted roles in mitochondrial function and is involved in the modulation of mitochondria-related diseases. This paper reviews the protective effects of AKT and its potential mechanisms of action in relation to mitochondrial function in various diseases.
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