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Related Experiment Video

Updated: Oct 4, 2025

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing
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Laryngeal allergy.

Kensei Naito1, Hisayuki Kato2, Yuki Inuzuka2

  • 1Academy of Nursing, Fujita Health University, Toyoake, Aichi, Japan.

Fujita Medical Journal
|February 3, 2022
PubMed
Summary

Chronic laryngeal allergy, causing persistent cough and globus, has evolved diagnostic criteria in Japan since 1995. Recent updates in 2011 and inclusion in JRS guidelines improve diagnosis and patient care.

Keywords:
Atopic coughChronic coughCough variant asthmaGastroesophageal reflux diseaseLaryngeal allergy

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Area of Science:

  • Otolaryngology
  • Allergology
  • Respiratory Medicine

Background:

  • Patients with allergic rhinitis often experience laryngeal symptoms like persistent cough and globus.
  • Chronic laryngeal allergy is a suspected primary cause of these laryngeal symptoms.
  • The concept of laryngeal allergy has been developed since 1988.

Purpose of the Study:

  • To review the evolution of diagnostic criteria for laryngeal allergy in Japan.
  • To highlight the importance of accurate diagnosis for effective management of cough and globus.
  • To emphasize the need for further research into laryngeal allergy and similar conditions.

Main Methods:

  • Review of historical diagnostic criteria for laryngeal allergy established in 1995, 2005, and 2011.
  • Analysis of the inclusion of chronic laryngeal allergy in the Japanese Respiratory Society (JRS) guidelines (2019).
  • Discussion of the clinical significance and diagnostic challenges.

Main Results:

  • Initial diagnostic criteria (1995) lacked distinction from other causes of cough and globus.
  • Revised criteria in 2005 and further modifications in 2011 improved diagnostic accuracy.
  • Chronic laryngeal allergy is now recognized in JRS guidelines, indicating wider acceptance.

Conclusions:

  • Diagnostic criteria for laryngeal allergy have progressively improved in accuracy and clinical utility.
  • Accurate diagnosis is crucial for managing persistent cough and globus, avoiding misdiagnosis and resource waste.
  • Continued research is necessary to deepen the understanding of laryngeal allergy and related disorders.