Low-dose CT with tin filter combined with iterative metal artefact reduction for guiding lung biopsy

Computed tomography (CT) is currently the imaging modality of choice for guiding pulmonary percutaneous procedures. The use of a tin filter allows low-energy photons to be absorbed which contribute little to image quality but increases the radiation dose that a patient receives. Iterative metal artefact reduction (iMAR) was developed to diminish metal artefacts. This study investigated the impact of using tin filtration combined with an iMAR algorithm on dose reduction and image quality in CT-guided lung biopsy.

Ninety-nine consecutive patients undergoing CT-guided lung biopsy were randomly assigned to routine-dose CT protocols (groups A and B; without and with iMAR, respectively) or tin filter CT protocols (groups C and D; without or with iMAR, respectively). Subjective image quality was analysed using a 5-point Likert scale. Objective image quality was assessed, and the noise, contrast-to-noise ratio, and figure of merit were compared among the four groups. Metal artefacts were quantified using CT number reduction and metal diameter blurring. The radiation doses, diagnostic performance, and complication rates were also estimated.

The subjective image quality of the two scan types was compared. Images with iMAR reconstruction were superior to those without iMAR reconstruction (group A: 3.49±0.65 vs. group B: 4.63±0.57; P<0.001, and group C: 3.88±0.66 vs. group D: 4.82±0.39; P<0.001). Images taken with a tin filter were found to have a significantly higher figure-of-merit than those taken without a tin filter (group A: 14,041±7,230 vs. group C: 21,866±10,656; P=0.001, and group B: 13,836±6,849 vs. group D: 21,639±9,964; P=0.001). In terms of metal artefact reduction, tin filtration combined with iMAR showed the lowest CT number reduction (116.62±103.48 HU) and metal diameter blurring (0.85±0.30) among the protocols. The effective radiation dose in the tin filter groups was 73.2% lower than that in the routine-dose groups. The complication rate and diagnostic performance (sensitivity, specificity, and overall accuracy) did not differ significantly between the tin filter and routine-dose groups (all P>0.05).

Tin filtration combined with an iMAR algorithm may reduce the radiation dose compared to the routine-dose CT protocol, while maintaining comparable diagnostic accuracy and image quality and producing fewer metal artefacts.