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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer

Jinjin Chu1, Xianzhu Fang2, Zhonghou Sun3

  • 1Central Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang, China.

Frontiers in Oncology
|February 3, 2022
PubMed

Insights

Non-coding RNAs (ncRNAs) are implicated in colorectal cancer (CRC) resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (McAbs). Understanding these ncRNAs offers new targets for improving CRC treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide, with increasing incidence.
  • Anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (McAbs) have improved outcomes for metastatic CRC (mCRC), but resistance remains a significant challenge.

Purpose of the Study:

  • To review the mechanisms by which non-coding RNAs (ncRNAs) regulate resistance to anti-EGFR McAbs in CRC.
  • To highlight the potential of ncRNAs as biomarkers and therapeutic targets for overcoming anti-EGFR therapy resistance in CRC.

Main Methods:

  • Literature review of studies investigating ncRNAs (miRNAs, lncRNAs, circRNAs) and their role in CRC.
  • Analysis of ncRNA involvement in tumorigenesis, tumor progression, and drug resistance mechanisms.

Main Results:

  • ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are key regulators of gene expression in CRC.
  • These ncRNAs play a crucial role in the development of resistance to anti-EGFR McAbs in CRC patients.
  • Specific ncRNAs have been identified as critical mediators of resistance pathways.

Conclusions:

  • ncRNAs are integral to the mechanisms underlying CRC resistance to anti-EGFR therapy.
  • Targeting ncRNAs presents a promising strategy for developing novel therapeutic approaches and prognostic markers for mCRC.
Keywords:
CRCEGFRcircRNAdrug resistancelncRNAmiRNA

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