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Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

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Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

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Multi-Functional Hypercrosslinked Polystyrene as High-Performance Adsorbents for Artificial Liver Blood Purification.

Yunhong Liu¹, Xinyan Peng¹

¹College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, China.

Frontiers in Chemistry

|February 3, 2022

Summary

A novel pyridinyl-modified hypercrosslinked polystyrene adsorbent offers efficient removal of diverse toxins from blood. This adsorbent shows promise for artificial liver blood purification systems due to its broad-spectrum adsorption and hemocompatibility.

Keywords:

adsorptive resin artificial liver blood purification hemocompatibility hemoperfusion hypercrosslinked polystyrene

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Area of Science:

Biomaterials Science
Chemical Engineering
Hepatology

Background:

Hemoperfusion for artificial liver support faces challenges with adsorbent capacity and biocompatibility.
Efficient removal of diverse toxic metabolites from whole blood remains a clinical hurdle.

Purpose of the Study:

To develop a novel adsorbent for enhanced artificial liver blood purification.
To create an adsorbent with high capacity for multiple toxins and improved hemocompatibility.

Main Methods:

Synthesized a pyridinyl-modified hypercrosslinked polystyrene (HCP) adsorbent, HCP(St-DVB-VP), via a novel Friedel-Crafts post-crosslinking reaction.
Characterized the adsorbent's porous structure, specific surface area, and adsorptive properties.
Evaluated in vitro hemocompatibility and adsorption of protein-bound and medium/large molecular toxins.

Main Results:

HCP(St-DVB-VP) exhibited a high specific surface area (761 m² g^-1) and a porous structure.
Demonstrated simultaneous excellent adsorption of bilirubin, PTH, and IL-6.
Showed acceptable hemocompatibility, indicating suitability for blood contact.

Conclusions:

The novel, low-cost, and eco-friendly adsorbent HCP(St-DVB-VP) offers broad-spectrum toxin removal.
Its favorable adsorptive capacity and hemocompatibility make it a promising candidate for clinical artificial liver blood purification.