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Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
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Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials
Sajad Najafi1, Soudeh Ghafouri-Fard2, Bashdar Mahmud Hussen3,4
1Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Frontiers in Cell and Developmental Biology
|February 3, 2022
Summary
The long noncoding RNA SNHG7 promotes cancer progression and is linked to poor prognosis and chemoresistance. This review highlights its potential as a prognostic, diagnostic, and therapeutic target in cancer.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) are key regulators of cellular processes.
- Dysregulation of lncRNAs, including SNHG7, is implicated in human cancers.
- SNHG7 is frequently upregulated and promotes malignant behaviors.
Purpose of the Study:
- To review recent research on SNHG7 in cancer.
- To explore the prognostic, diagnostic, and therapeutic potential of SNHG7.
Main Methods:
- Literature review of studies across cellular, animal, and human experiments.
- Analysis of SNHG7's molecular mechanisms and clinical associations.
Main Results:
- SNHG7 promotes cancer cell growth, invasion, and metastasis.
- SNHG7 interacts with miRNAs, signaling pathways, and proteins to drive tumorigenesis.
- High SNHG7 expression correlates with adverse clinicopathological features, poor prognosis, and chemoresistance.
Conclusions:
- SNHG7 is a promising biomarker for cancer prognosis and diagnosis.
- Targeting SNHG7 offers potential therapeutic strategies for cancer treatment.
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