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Updated: Oct 4, 2025

Molecular Imaging to Target Transplanted Muscle Progenitor Cells
Published on: March 27, 2013
Molecular Prosthetics for Long-Term Functional Imaging with Fluorescent Reporters
Vincent Grenier1, Kayli N Martinez1, Brittany R Benlian1
1Department of Chemistry and Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute. University of California, Berkeley, California 94720, United States.
Abstract:
Voltage-sensitive fluorescent reporters can reveal fast changes in the membrane potential in neurons and cardiomyocytes. However, in many cases, illumination in the presence of the fluorescent reporters results in disruptions to the action potential shape that limits the length of recording sessions. We show here that a molecular prosthetic approach, previously limited to fluorophores, rather than indicators, can be used to substantially prolong imaging in neurons and cardiomyocytes.
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