Meningoencephalitis caused by Fusarium proliferatum: an unusual case

Ilad Alavi Darazam1,2, Guive Sharifi3, Elena Jamali4

  • 1Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ilad13@yahoo.com.

Infection
|February 3, 2022
PubMed

Insights

This case study highlights a rare instance of meningoencephalitis caused by Fusarium proliferatum, a fungal infection, in a patient with rheumatoid arthritis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Meningoencephalitis presents diagnostic challenges, with infectious etiologies including fungi.
  • Fusarium species are recognized as significant invasive fungal pathogens.
  • Central nervous system (CNS) infections by Fusarium are uncommon, typically arising from hematogenous spread.

Observation:

  • This report details an unusual case of meningoencephalitis.
  • The causative agent identified was Fusarium proliferatum.
  • The patient had a pre-existing diagnosis of rheumatoid arthritis.

Findings:

  • Fusarium proliferatum was confirmed as the cause of meningoencephalitis.
  • The infection occurred in an immunocompromised patient with rheumatoid arthritis.
  • This case underscores the potential for Fusarium to cause rare CNS infections.

Implications:

  • Highlights the importance of considering rare fungal pathogens in CNS infections.
  • Suggests that patients with autoimmune diseases like rheumatoid arthritis may be at risk.
  • Emphasizes the need for timely diagnosis and appropriate antifungal treatment for CNS fusariosis.

Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
157
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
248
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
310
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
241