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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Olfaction01:25

Olfaction

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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Physiology of Smell and Olfactory Pathway01:20

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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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Related Experiment Video

Updated: Oct 4, 2025

Selective Viral Transduction of Adult-born Olfactory Neurons for Chronic in vivo Optogenetic Stimulation
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Omega-3 supplementation in postviral olfactory dysfunction: a pilot study.

A K Hernandez1, D Woosch1, A Haehner1

  • 1Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.

Rhinology
|February 3, 2022
PubMed
Summary
This summary is machine-generated.

Omega-3 supplementation may enhance olfactory recovery in patients with postviral olfactory dysfunction. This adjunct therapy, combined with olfactory training, showed more pronounced improvements in odor thresholds compared to training alone.

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Area of Science:

  • Neurology
  • Otolaryngology
  • Nutritional Science

Background:

  • Postviral olfactory dysfunction is a common and distressing condition.
  • Olfactory training is a standard treatment, but recovery can be slow or incomplete.
  • Investigating adjunct therapies to improve olfactory recovery is crucial.

Purpose of the Study:

  • To evaluate the efficacy of omega-3 fatty acid supplementation as an adjunct to olfactory training for postviral olfactory dysfunction.
  • To determine if omega-3 supplementation can accelerate or improve olfactory recovery.

Main Methods:

  • A prospective, non-blinded pilot study included patients with postviral olfactory dysfunction.
  • Participants received either olfactory training alone (control) or olfactory training with omega-3 supplementation (treatment).
  • Olfactory function was assessed using 'Sniffin' Sticks' before and after a 3-month intervention period.

Main Results:

  • An overall improvement in olfactory scores was observed in both groups.
  • The omega-3 supplementation group demonstrated a more significant improvement in odor thresholds compared to the control group.
  • Age, sex, and symptom duration did not influence olfactory recovery outcomes.

Conclusions:

  • Omega-3 supplementation shows promise as an adjunctive therapy for postviral olfactory dysfunction.
  • Combining omega-3s with olfactory training may offer a beneficial treatment option.
  • Further research is warranted to confirm these findings in larger trials.