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Relationship between arterial and venous bicarbonate values.

R E Brashear, T O Oei, M L Rhodes

    Archives of Internal Medicine
    |April 1, 1979
    PubMed
    Summary
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    Venous CO2 measurements correlate significantly with arterial bicarbonate levels, aiding acid-base management. However, venous CO2 should not replace arterial blood gas analysis for critical calculations.

    Area of Science:

    • Clinical Chemistry
    • Acid-Base Balance
    • Diagnostic Monitoring

    Background:

    • Accurate acid-base status assessment is crucial for patient management.
    • Routine electrolyte panels offer venous CO2 content, a potentially accessible surrogate for arterial bicarbonate.

    Purpose of the Study:

    • To evaluate the clinical utility of venous CO2 measurements in acid-base management.
    • To establish correlations and predictive equations between venous CO2 and arterial bicarbonate.
    • To assess the impact of preanalytical factors on venous CO2 stability.

    Main Methods:

    • Collected paired venous and arterial blood samples from 336 patients.
    • Measured venous CO2 content, chloride, and arterial blood gases (pH, PaO2, PaCO2).
    • Analyzed linear correlation and developed prediction equations for arterial bicarbonate.

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    Main Results:

    • A significant linear correlation (P < .001) was found between calculated arterial HCO3- and measured venous CO2.
    • Prediction equations using venous CO2, chloride, and arterial pH were derived.
    • Preanalytical factors like time delay and air exposure were assessed for their effects on venous CO2.

    Conclusions:

    • Venous CO2 measurements show a strong correlation with arterial bicarbonate, offering potential clinical insights.
    • Venous CO2 should not substitute arterial bicarbonate in the Henderson-Hasselbalch equation for precise pH/PaCO2 calculations.
    • Abnormal venous CO2 levels warrant further arterial blood gas analysis for definitive assessment.