Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

7.0K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
7.0K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

6.7K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.7K
Apoptosis01:30

Apoptosis

12.1K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
12.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

4.1K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LIG1 Loss in TP53-mutant Triple Negative Breast Cancer Rewires DNA Repair and Confers Sensitivity to PARP-ATR Inhibitor Combinations.

Molecular cancer therapeutics·2026
Same author

ASO Visual Abstract: Streamlining the Abstract Selection Process for the American Society of Breast Surgeons' Annual Meeting by Utilizing Large Language Models.

Annals of surgical oncology·2026
Same author

Restrictive Vs. Standard Fluid Management in Mechanically Ventilated Children Admitted to PICU: A Pilot Randomized Controlled Trial.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Taking Leave During Breast Surgical Oncology Fellowship: A National Evaluation of Policy and Practice.

Annals of surgical oncology·2026
Same author

Streamlining the Abstract Selection Process for the American Society of Breast Surgeons' Annual Meeting by Utilizing Large Language Models.

Annals of surgical oncology·2026
Same author

Active monitoring versus surgical excision for atypical ductal hyperplasia.

Cancer prevention research (Philadelphia, Pa.)·2026

Related Experiment Video

Updated: Oct 4, 2025

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
09:57

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

Published on: January 29, 2019

22.8K

Targeting Apoptosis in Cancer.

Puneet Singh1, Bora Lim2,3

  • 1Division of Surgery, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Psingh6@mdanderson.org.

Current Oncology Reports
|February 3, 2022
PubMed
Summary

Cancer cells evade apoptosis, leading to therapy resistance. New apoptosis modulators, like MDM2 and kinase inhibitors, show promise in overcoming this resistance and offer a potential therapeutic strategy.

Keywords:
Anti-cancer therapeuticsApoptosisBH3CancerExtrinsic apoptosis pathwayIntrinsic apoptosis pathway

More Related Videos

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
12:28

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Published on: January 11, 2019

7.5K
Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.8K

Related Experiment Videos

Last Updated: Oct 4, 2025

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
09:57

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

Published on: January 29, 2019

22.8K
Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
12:28

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Published on: January 11, 2019

7.5K
Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.8K

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Apoptosis is a critical mechanism for cancer cell death.
  • Evasion of apoptosis contributes to therapeutic resistance in cancer.
  • Understanding apoptosis pathways is key to developing novel cancer treatments.

Purpose of the Study:

  • To review recent developments in apoptosis modulators for cancer therapy.
  • To highlight novel agents targeting apoptosis pathways.
  • To assess the therapeutic potential of apoptosis-targeting strategies.

Main Methods:

  • Review of current literature on apoptosis modulators in cancer.
  • Analysis of recent advancements in medicinal chemistry and molecular biology.
  • Examination of clinical trial data for apoptosis-targeting agents.

Main Results:

  • Dysregulation of both extrinsic and intrinsic apoptosis pathways contributes to cancer.
  • MDM2 inhibitors and kinase inhibitors are emerging as effective apoptosis inducers.
  • Several novel apoptosis-targeting agents are currently in early-phase clinical trials.

Conclusions:

  • Targeting apoptosis remains a promising strategy in cancer therapeutics.
  • Despite development challenges, apoptosis modulators offer potential for overcoming therapy resistance.
  • Continued research in medicinal chemistry and molecular biology is crucial for advancing apoptosis-based cancer treatments.