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Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Manoj Kumar1, Zaigham Abbas2, Milad Azami3

  • 1Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. manojkumardm@gmail.com.

Hepatology International
|February 3, 2022
PubMed

Insights

Hepatitis B virus (HBV) infection management during pregnancy is crucial in Asia-Pacific. These guidelines offer recommendations for pregnant individuals with HBV and their infants, addressing critical care and follow-up strategies.

Area of Science:

  • Hepatology
  • Public Health
  • Infectious Diseases

Background:

  • Hepatitis B virus (HBV) infection is a significant public health concern in the Asia-Pacific region.
  • Perinatal and early childhood exposure contribute substantially to the HBV disease burden.
  • Pregnancy with Hepatitis B presents unique challenges for maternal and fetal health.

Purpose of the Study:

  • To provide comprehensive guidelines for managing females with HBV infection throughout pregnancy and postpartum.
  • To address specific concerns and management challenges related to HBV in pregnant individuals.
  • To outline follow-up protocols for infants born to mothers with Hepatitis B.

Main Methods:

  • Systematic review of existing literature on HBV management in pregnancy.
  • Evidence-based recommendations developed by the Asia-Pacific Association for the Study of the Liver (APASL).
  • Focus on all stages of pregnancy, postpartum period, and infant care.

Main Results:

  • Detailed recommendations for antiviral therapy and monitoring during pregnancy.
  • Strategies for preventing perinatal transmission of HBV.
  • Guidance on infant vaccination and follow-up protocols.

Conclusions:

  • Effective management of HBV in pregnant individuals is essential for maternal and infant outcomes.
  • Adherence to APASL guidelines can mitigate the impact of HBV infection in the Asia-Pacific region.
  • Comprehensive care throughout pregnancy, postpartum, and infancy is critical for controlling HBV-related diseases.

Keywords:
Acute Hepatitis BChronic Hepatitis BHepatitis BPregnancy

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