Related Experiment Video
Updated: Oct 4, 2025

Author Spotlight: Advancing Cellular and Protein Engineering to Control Biological Functions and Develop Novel Therapies
Published on: September 27, 2024
Effect of Affinity between Dechlorane Plus and Human Serum Albumin on Its Serum Concentration in a General Population
Junsong Bao1, Lei Hou1,2, Ying Wang1,3
1College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China.
Abstract:
Dechlorane Plus (DP) has been detected in human serum around the world. Determining how DP binds to human serum albumin (HSA) could improve our understanding of the effects of DP in humans. The results of a fluorescence titration experiment indicated that DP binds to HSA at the interface between domains IIA and IIB, and HSA has more affinity for anti-DP than syn-DP. The DP concentrations in serum from 33 people living in Wuxi City, China, were determined in five consecutive years (2012-2016). The total concentrations of the two DP isomers were 1.73-16.3 ng·g-1 lipid weight (mean 4.7 ng·g-1 lipid weight). No clear increasing or decreasing temporal trend was found in the DP concentrations in serum over the study period. The affinity between DP and HSA will increase as the amount of fatty acids combined with HSA increases. This explained the syn-DP and anti-DP concentrations in serum being higher for overweight people than for normal weight people. Ethanol can occupy the DP binding sites on HSA. This explained the syn-DP and anti-DP concentrations being lower for alcoholic people than for nonalcoholic people.
Related Concept Videos
Drug Distribution: Plasma Protein Binding
Factors Affecting Protein-Drug Binding: Patient-Related Factors
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Factors Affecting Protein-Drug Binding: Protein-Related Factors
The physicochemical properties of a drug play a significant role in its ability to bind to proteins. Lipophilic drugs, which dissolve in fats, oils, and lipids, can be...
Factors Affecting Drug Distribution: Miscellaneous Factors
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Drug Concentrations: Measurements
Plasma...
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

