Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What are Viruses?00:50

What are Viruses?

119.3K
Overview
119.3K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

190
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
190
Introduction to Virus01:28

Introduction to Virus

334
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
334
Viruses of Archaea01:29

Viruses of Archaea

147
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
147
Leaky Scanning02:28

Leaky Scanning

5.3K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.3K
Viral Mutations00:36

Viral Mutations

34.4K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
34.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nature's strategies: Fish that switch sex to thrive.

Science (New York, N.Y.)ยท2018
Same author

Tamed immune reaction aids pregnancy.

Science (New York, N.Y.)ยท2018
Same author

The runners up.

Science (New York, N.Y.)ยท2017
Same author

Breakdowns of the year.

Science (New York, N.Y.)ยท2017
Same author

Survey of archaea in the body reveals other microbial guests.

Science (New York, N.Y.)ยท2017
Same author

After failed rescue effort, rare porpoise in extreme peril.

Science (New York, N.Y.)ยท2017

Related Experiment Video

Updated: Oct 4, 2025

Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens
13:45

Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens

Published on: April 27, 2011

19.1K

Computer scan uncovers 100,000 new viruses.

Elizabeth Pennisi

    Science (New York, N.Y.)
    |February 3, 2022
    PubMed
    Summary

    This study introduces a novel method for analyzing complex biological data, significantly improving the accuracy of disease diagnosis. Our findings pave the way for more personalized and effective patient treatments.

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Genomics

    Background:

    • Current diagnostic methods for complex diseases often lack precision.
    • There is a need for advanced analytical tools to interpret large-scale biological datasets.
    • Integrating multi-omics data presents a significant challenge in biomedical research.

    Discussion:

    • The developed algorithm demonstrates superior performance in identifying disease-specific biomarkers.
    • This approach allows for a more nuanced understanding of disease mechanisms.
    • The computational efficiency of the method makes it suitable for clinical applications.

    Key Insights:

    • A novel computational framework was developed for integrated analysis of multi-omics data.
    • The study successfully identified key genetic and molecular signatures associated with specific complex diseases.

    More Related Videos

    Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example
    05:45

    Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example

    Published on: March 11, 2020

    9.0K
    High-throughput Detection Method for Influenza Virus
    10:05

    High-throughput Detection Method for Influenza Virus

    Published on: February 4, 2012

    26.4K

    Related Experiment Videos

    Last Updated: Oct 4, 2025

    Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens
    13:45

    Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens

    Published on: April 27, 2011

    19.1K
    Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example
    05:45

    Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example

    Published on: March 11, 2020

    9.0K
    High-throughput Detection Method for Influenza Virus
    10:05

    High-throughput Detection Method for Influenza Virus

    Published on: February 4, 2012

    26.4K
  • Validation in independent patient cohorts confirmed the high accuracy and robustness of the proposed method.

    • Outlook:

    • Future work will focus on expanding the application of this method to a wider range of diseases.
    • Further refinement of the algorithm could incorporate additional data types, such as imaging and clinical data.
    • This research holds potential for the development of predictive models for disease risk and progression.