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Botulinum toxin for treating overactive bladder in men: A systematic review.
Jose C Truzzi1,2, Marie C Lapitan3,4, Natassia C Truzzi5
1Department of Urology, Instituto de Cancer Arnaldo Vieira de Carvalho, Sao Paulo, Brazil.
Neurourology and Urodynamics
|February 3, 2022
Summary
Botulinum toxin (BTX-A) injections show limited evidence for treating overactive bladder (OAB) in men, with reported adverse events including urinary tract infections and retention. Further research is needed to clarify its risk-benefit profile in this population.
Area of Science:
- Urology
- Pharmacology
Background:
- Overactive bladder (OAB) significantly impacts quality of life.
- Botulinum toxin type A (BTX-A) is an established treatment for OAB in women.
- Evidence for BTX-A in male OAB is less established.
Purpose of the Study:
- To systematically review the literature on the efficacy and safety of BTX-A bladder injections for treating OAB in men.
Main Methods:
- Systematic review of clinical trials from inception to October 2020.
- Included studies assessed efficacy and safety of BTX-A in the detrusor muscle.
- Quality assessment used Cochrane Collaboration's tool; data extracted independently by two reviewers.
Main Results:
- Twelve trials were included, with 6 exclusively in men (mean age 66.7 years).
- Limited randomized controlled trials; mostly observational studies and case series.
- Adverse events reported in seven studies included UTI (29.8%), urinary retention (20.0%), and increased postvoid residual (37.3%).
Conclusions:
- Limited evidence exists on BTX-A efficacy and safety for male OAB.
- Further research is required to establish the risk-benefit profile in men.
- Current data suggests potential adverse events that warrant careful consideration.
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