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Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
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Consensus guidelines and recommendations for infection prevention in multiple myeloma: a report from the

Noopur S Raje1, Elias Anaissie2, Shaji K Kumar3

  • 1Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

The Lancet. Haematology
|February 3, 2022
PubMed

Insights

Preventing infections is crucial for multiple myeloma patients due to high morbidity and mortality risks. This review offers expert consensus recommendations for infection prevention strategies, including vaccination and prophylaxis.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Oncology

Background:

  • Infection is a primary cause of death in multiple myeloma patients.
  • Risk factors include disease, treatment, and patient-related elements.
  • Existing infection prevention guidelines lack universal acceptance.

Purpose of the Study:

  • To provide expert consensus recommendations for preventing infectious complications in multiple myeloma.
  • To address infection risks in the context of novel therapies.
  • To review current literature and guidelines on infection prevention.

Main Methods:

  • A panel of 36 international experts was convened by The International Myeloma Society.
  • The panel reviewed existing literature and current guidelines.
  • A consensus statement was developed based on expert review and discussion.

Main Results:

  • Infection prevention strategies include vaccination, antimicrobial prophylaxis, infection control, and immunoglobulin replacement.
  • No universally accepted guidelines currently exist for infection prevention in multiple myeloma.
  • Emerging therapies necessitate updated approaches to infection risk management.

Conclusions:

  • Proactive and comprehensive infection prevention is essential for improving outcomes in multiple myeloma.
  • Expert consensus provides a framework for managing infectious complications.
  • Further research and guideline development are needed to optimize patient care.

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