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Updated: Oct 4, 2025

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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The Keystones of Right Ventricular Arrhythmogenic Cardiomyopathy-Induced Morphological Disarrangement

Ashot Avagimyan1, Lev Kakturskiy2, Liana Gogiashvili3

  • 1Lecturer of Pathological Anatomy and Clinical Morphology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia.

Current Problems in Cardiology
|February 3, 2022
PubMed

Insights

Arrhythmogenic right ventricular cardiomyopathy (ARVC) involves heart muscle remodeling due to genetic mutations. Athletes face higher risks, highlighting the need for better diagnostics and treatments for this heterogeneous cardiac condition.

Area of Science:

  • Cardiology
  • Genetics
  • Sports Medicine

Background:

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a significant cardiac issue.
  • It involves myocardial remodeling, desmosopathies, and channelopathies, disrupting coordinated heart function.
  • Athletes are a high-risk group, underscoring the clinical relevance.

Purpose of the Study:

  • To detail the pathophysiological mechanisms of ARVC.
  • To explore the molecular genetic aspects of the disease.
  • To analyze the dynamics of morphofunctional changes in ARVC.

Main Methods:

  • Review of current literature on ARVC.
  • Analysis of genetic mutations associated with ARVC.
  • Examination of pathophysiological pathways and morphological alterations.

Main Results:

  • ARVC is characterized by heterogeneous clinical presentations.
  • Genetic factors and desmosomal abnormalities are key to ARVC pathogenesis.
  • Morphofunctional changes dynamically evolve in affected individuals.

Conclusions:

  • Understanding ARVC's etiopathogenesis is crucial for developing advanced treatments.
  • Optimizing diagnostic methods and treatment protocols is essential for improving patient outcomes.
  • Further research into ARVC mechanisms will enhance quality of life and life expectancy.

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