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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
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Inflammation as a Mechanism and Therapeutic Target in Peripheral Artery Disease

Noel C Chan1, Ke Xu2, Tim A C de Vries3

  • 1Population Health Research Institute, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

The Canadian Journal of Cardiology
|February 3, 2022
PubMed

Insights

Peripheral artery disease (PAD) patients face high vascular risks despite treatments. This review explores inflammation

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Atherosclerosis Studies

Background:

  • Peripheral artery disease (PAD) is a major manifestation of atherosclerosis, alongside coronary and cerebrovascular disease.
  • Current treatments for PAD, including surgery and risk factor modification, leave patients with significant residual vascular risk.
  • Inflammation is increasingly recognized as a key driver in the development and progression of atherosclerosis.

Purpose of the Study:

  • To review the evidence linking inflammation to atherosclerosis pathogenesis.
  • To examine recent clinical trials of anti-inflammatory agents for atherothrombosis.
  • To identify novel anti-inflammatory strategies for PAD complications.

Main Methods:

  • Literature review of studies on inflammation in atherosclerosis.
  • Analysis of clinical trial data for anti-inflammatory therapies.
  • Synthesis of evidence on therapeutic opportunities for PAD.

Main Results:

  • Inflammation plays a critical role in the development of atherosclerosis and its complications.
  • Existing anti-inflammatory approaches show promise but require further investigation for PAD.
  • Novel anti-inflammatory strategies may offer new avenues for reducing cardiovascular and limb risks in PAD patients.

Conclusions:

  • Targeting inflammation presents a promising strategy to mitigate residual risk in peripheral artery disease.
  • Further research into novel anti-inflammatory agents is warranted to improve outcomes for PAD patients.
  • Addressing the inflammatory component of atherosclerosis is crucial for comprehensive atherothrombosis prevention and treatment.

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