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A Novel Chemical Binding Primer to Improve Dentin Bonding Durability
1Department of Prosthetic Dentistry, School and Hospital of Stomatology, Jilin University, Changchun, P.R. China.
Journal of Dental Research
|February 4, 2022
Summary
A new primer, 4-formylphenyl acrylate (FA), covalently bonds to dentin collagen, enhancing stability against degradation. This improves bonding performance in dentistry without affecting adhesive conversion rates.
Area of Science:
- Biomaterials Science
- Dental Materials Science
- Polymer Chemistry
Background:
- Dentin collagen is vulnerable to degradation by collagenases during dental adhesive procedures.
- Current dental adhesives lack components for covalent bonding to dentin collagen, compromising bond durability.
- The etch-and-rinse process can lead to deterioration of the bonding interface due to incomplete resin infiltration.
Purpose of the Study:
- To synthesize and evaluate 4-formylphenyl acrylate (FA) as a novel photocurable primer for covalent bonding to dentin collagen.
- To assess the biocompatibility, dentin modification capabilities, and bonding performance of FA-based primers.
- To investigate the effect of FA on the stability of the dentin collagen matrix and the penetration of adhesive resins.
Main Methods:
- Synthesis of 4-formylphenyl acrylate (FA) and preparation of experimental primers with varying FA concentrations.
- Cytotoxicity evaluation using live/dead-cell staining and MTT assay.
- Analysis of FA-collagen interaction via FTIR, hydroxyproline release assay, and TGA.
- Assessment of bonding performance using microtensile bond strength testing before and after aging.
- Microscopic observation of the bonding interface using CLSM and SEM.
Main Results:
- FA demonstrated good biocompatibility and effectively cross-linked dentin collagen, enhancing stability against enzymatic degradation.
- FA improved dentin modification and infiltration, potentially acting as a diluting monomer for deeper adhesive penetration.
- Microtensile bond strength after aging was significantly improved without compromising the degree of conversion of commercial adhesives.
- FA successfully modified the adhesive interface, leading to enhanced bonding durability.
Conclusions:
- 4-formylphenyl acrylate (FA) is a promising primer for adhesive dentistry, offering covalent bonding to dentin collagen.
- FA enhances the stability of the dentin collagen matrix and improves the overall bonding performance and durability.
- The application of FA represents a significant advancement in improving the longevity of dental adhesive restorations.
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