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Updated: Oct 4, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties
Ban-Feng Ruan1,2, Qing-Lei Guo2, Qing-Shan Li2
1Key Lab of Biofabrication of Anhui Higher Education, Hefei University, Hefei, 230601, P.R. China.
Abstract:
The oxadiazole core is considered a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,5-oxadiazole. Compounds bearing an oxadiazole ring show a wide range of biological activities, such as anticancer, antibacterial, anti-inflammatory, anti-malarial, and insecticidal properties. Among oxadiazoles, the 1,3,4-oxadiazole has been the most widely explored moiety in medicinal chemistry research. This review is primarily focused on the anticancer, antibacterial, and anti-inflammatory activities of compounds containing 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole reported in the last five years.
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Separation of...
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

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