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Updated: Oct 4, 2025

Development of Whispering Gallery Mode Polymeric Micro-optical Electric Field Sensors

Development of Whispering Gallery Mode Polymeric Micro-optical Electric Field Sensors

Published on: January 29, 2013

Single-molecule optofluidic microsensor with interface whispering gallery modes.

Xiao-Chong Yu^1,2,3,4, Shui-Jing Tang^1,2, Wenjing Liu^1,2

¹State Key Laboratory for Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China.

Proceedings of the National Academy of Sciences of the United States of America

|February 4, 2022

Summary

This summary is machine-generated.

This study introduces an ultrasensitive optofluidic biosensor using microbubble cavities for label-free biological analysis. It achieves a low detection limit and minimal sample consumption, enabling sensitive disease diagnosis.

Keywords:

interfacial molecular detection optofluidic biosensor whispering gallery microresonator

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Last Updated: Oct 4, 2025

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Area of Science:

Biomedical Engineering
Optics and Photonics
Biosensing Technologies

Background:

Label-free sensors are crucial for biological analysis and disease diagnosis.
Optical evanescent sensors offer label-free detection but are limited by weak evanescent fields.
Existing biosensors require further improvements in sensitivity and sample volume.

Purpose of the Study:

To develop an ultrasensitive optofluidic biosensor with enhanced evanescent field intensity.
To overcome the limitations of traditional optical evanescent sensors.
To achieve highly sensitive detection with minimal sample consumption.

Main Methods:

Utilized interface whispering gallery modes within a microbubble cavity.
Integrated microfluidic channels for sample delivery.
Employed plasmonic enhancement for improved signal detection.

Main Results:

Achieved a low detection limit of 0.3 pg/cm².
Required only 10 pL of sample volume.
Demonstrated detection of single DNA molecules (8 kDa) using plasmon-enhanced interface modes.

Conclusions:

The developed optofluidic biosensor offers unprecedented sensitivity and efficiency for label-free detection.
Interface whispering gallery modes in microbubble cavities significantly enhance sensing capabilities.
This technology holds great potential for early-stage disease diagnosis and sensitive biological analysis.