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Updated: Oct 4, 2025

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Blood Pressure Rhythm and Blood Pressure Variability as Risk Factors for White Matter Lesions: A Cross-Sectional

Dong Zhang1, Mingli He2, Qing He1

  • 1Department of Neurology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|February 4, 2022
PubMed

Insights

Disrupted blood pressure rhythms and increased blood pressure variability are linked to reduced regional cerebral blood flow in individuals with white matter lesions. These findings highlight the importance of monitoring blood pressure patterns in elderly populations.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Medical Imaging

Background:

  • White matter lesions are prevalent in the elderly population.
  • Understanding their association with cardiovascular factors is crucial for geriatric health.

Purpose of the Study:

  • To investigate the correlation between blood pressure rhythm and variability with white matter lesions.
  • To assess the impact of these blood pressure parameters on regional cerebral blood flow.

Main Methods:

  • 144 subjects (40-80 years) underwent MRI for white matter lesion assessment (Fazekas scale).
  • Brain perfusion imaging measured regional cerebral blood flow.
  • Ambulatory blood pressure monitoring assessed circadian blood pressure rhythm.
  • Logistic regression and curve simulation analyzed associations.

Main Results:

  • Increased white matter lesions correlated with decreased regional cerebral blood flow.
  • Systolic and diastolic blood pressure day/night difference ratios and coefficients of variation were significantly associated with white matter lesion severity (Fazekas score).
  • Specific odds ratios and confidence intervals were reported for these associations.

Conclusions:

  • Greater blood pressure variability and disorders in blood pressure rhythm are associated with diminished regional cerebral blood flow.
  • These findings suggest a link between abnormal blood pressure dynamics and cerebrovascular changes in white matter lesions.

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