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Related Experiment Videos

Tardive dyskinesia--reversible and persistent.

D V Jeste, S G Potkin, S Sinha

    Archives of General Psychiatry
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Frequent drug interruptions may not prevent tardive dyskinesia in predisposed patients. This study found longer neuroleptic treatment and more drug-free intervals were linked to persistent dyskinetic symptoms.

    Area of Science:

    • Neurology
    • Psychiatry

    Background:

    • Tardive dyskinesia is a potential side effect of long-term neuroleptic and antidepressant use.
    • The role of drug withdrawal and treatment interruptions in the development of tardive dyskinesia is debated.

    Purpose of the Study:

    • To investigate the relationship between drug-free intervals and the persistence of tardive dyskinesia.
    • To identify factors differentiating reversible from persistent tardive dyskinesia.

    Main Methods:

    • Studied 21 hospitalized patients over 50 with tardive dyskinesia for 13 months.
    • Assessed symptom changes after a three-month withdrawal of neuroleptics and antidepressants.
    • Used discriminant function analysis to identify predictors of persistent dyskinesia.

    Main Results:

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    • Twelve patients (57%) showed symptom abatement, while nine (43%) had persistent dyskinesia after drug withdrawal.
    • Discriminant analysis clearly separated persistent and reversible dyskinesia groups.
    • The number of drug-free intervals was the strongest discriminator.
    • Patients with persistent dyskinesia had longer neuroleptic treatment (mean 10.8 years) and more frequent, lengthy drug interruptions (mean 5.6 intervals).

    Conclusions:

    • Findings do not support the idea that frequent, lengthy drug interruptions reduce persistent tardive dyskinesia incidence in predisposed individuals.
    • Longer neuroleptic exposure and a history of multiple drug interruptions may be associated with persistent dyskinesia.