Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.4K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.4K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.4K
The Thyroid Gland01:23

The Thyroid Gland

4.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.6K
Volume of Distribution01:20

Volume of Distribution

566
The apparent volume of distribution (Vd) is a crucial pharmacokinetic parameter representing the hypothetical body fluid volume into which a drug disperses. It is calculated based on the total amount of drug in the body (estimated from the administered dose and bioavailability) divided by the plasma drug concentration. The total amount of drug in the body does not directly refer to the dose given but is derived by accounting for absorption, distribution, metabolism, and excretion processes.
566
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.1K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated machine learning assisted fluorescent sensor array based on silver nanoclusters for detection of multiple heavy metal ions.

Mikrochimica acta·2026
Same author

Case Report: Indocyanine green fluorescence imaging in complex focal nodular hyperplasia resection: report of two cases.

Frontiers in medicine·2026
Same author

Multi-state electromagnetic phase modulations in NiCo<sub>2</sub>O<sub>4</sub> through cation disorder and hydrogenation.

Materials horizons·2026
Same author

Fabrication of Novel Yellow-Fluorescent Carbon Dots and Their Application for Fe³⁺ Detection.

Journal of fluorescence·2026
Same author

Functional Divergence of Mucus in Pacific Oyster (Crassostrea gigas): Insights From Integrated Proteomic and Rheological Study.

Proteomics·2026
Same author

Integrative Multiomics and Network Pharmacology Exploration of Active Components and Mechanisms of Action of Qufu Shengxin Ointment in Treating Chronic Nonhealing Wounds.

Mediators of inflammation·2026

Related Experiment Video

Updated: Oct 4, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

766

Association Between Red Blood Cell Distribution Width and Thyroid Function.

Guowei Zhou1, Yueqin Ai2, Song Guo1

  • 1Department of General Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Frontiers in Endocrinology
|February 4, 2022
PubMed
Summary
This summary is machine-generated.

Red blood cell distribution width (RDW) is linked to thyroid function, particularly thyroid-stimulating hormone (TSH) and free triiodothyronine (fT3). Elevated RDW may indicate subclinical hypothyroidism.

Keywords:
NHANEScross-sectional studyred blood cell distribution widthsubclinical hypothyroidismthyroid

More Related Videos

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.0K
Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
03:35

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

Published on: December 1, 2023

394

Related Experiment Videos

Last Updated: Oct 4, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

766
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.0K
Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
03:35

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

Published on: December 1, 2023

394

Area of Science:

  • Endocrinology
  • Hematology
  • Public Health

Background:

  • Red blood cell distribution width (RDW) has diverse biological roles.
  • Research on the association between RDW and thyroid function is limited and inconsistent.
  • Investigating this relationship in the US population is warranted.

Purpose of the Study:

  • To examine the association between RDW and thyroid function parameters in a large US adult population.
  • To explore potential nonlinear relationships between RDW and thyroid markers.

Main Methods:

  • Cross-sectional analysis of NHANES data (2007-2010).
  • Included 6,895 adults aged 18+.
  • Logistic regression and generalized additive models used to assess RDW and thyroid parameters (fT3, fT4, TSH, TgAb, TPOAb).

Main Results:

  • A J-shaped association was observed between RDW and TSH, with a positive relationship in the 12.5%-17.5% RDW range.
  • A significant negative association was found between RDW and fT3.
  • Elevated RDW was linked to a higher likelihood of subclinical hypothyroidism; no clear association with fT4.

Conclusions:

  • Confirmed a significant association between RDW and TSH.
  • The RDW-fT3 relationship requires further mechanistic investigation.
  • RDW may serve as a valuable clinical indicator for subclinical hypothyroidism.