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Squaring the circle: sponging microRNAs in gastric cancer

Steven G Gray1,2,3,4

  • 1Thoracic Oncology Research Group, Rm 2.09, Trinity Translational Medical Institute, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland.

Translational Cancer Research
|February 4, 2022
PubMed
Abstract

No abstract available in PubMed .

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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