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Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

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Circular RNA expression pattern in cisplatin-resistant osteosarcoma cells.

Jianhua Han¹, Zhiqiang Ye¹, Qinglei Kong¹

¹Department of Emergency, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

Translational Cancer Research

|February 4, 2022

Summary

This summary is machine-generated.

Circular RNAs (circRNAs) show distinct expression profiles in cisplatin-resistant osteosarcoma (OS) cells. Three specific circRNAs (hsa_circ_0008336, hsa_circ_0004664, hsa_circ_0003302) were upregulated, suggesting their potential role in OS cisplatin resistance.

Keywords:

Circular RNA (circRNA)RNA sequencing (RNA-seq)cisplatin osteosarcoma (OS)

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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

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Published on: February 6, 2015

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Cisplatin resistance is a significant challenge in osteosarcoma (OS) treatment.
The role of circular RNAs (circRNAs) in OS cisplatin resistance remains largely unexplored.

Purpose of the Study:

To investigate the expression profile of circRNAs associated with cisplatin resistance in OS.
To identify specific circRNAs that may contribute to cisplatin resistance in OS.

Main Methods:

Induction of cisplatin-resistant OS cell lines (U2OS-R and MG63-R).
RNA sequencing (RNA-seq) to identify differentially expressed circRNAs.
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.
Quantitative real-time polymerase chain reaction (qRT-PCR) for validation.

Main Results:

A total of 343 circRNAs were differentially expressed in cisplatin-resistant OS cells.
253 circRNAs were upregulated and 90 were downregulated.
Three circRNAs (hsa_circ_0008336, hsa_circ_0004664, and hsa_circ_0003302) were consistently upregulated in both resistant cell lines.
Enrichment analysis indicated involvement in cancer pathways and metabolic processes.

Conclusions:

Cisplatin-resistant OS cells exhibit a unique circRNA expression signature.
Upregulated circRNAs, specifically hsa_circ_0008336, hsa_circ_0004664, and hsa_circ_0003302, are potential biomarkers and therapeutic targets for overcoming cisplatin resistance in OS.