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Related Experiment Video

Updated: Oct 4, 2025

Culturing and Manipulation of O9-1 Neural Crest Cells
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High neural precursor cell-expressed developmentally down-regulated 9 expression is a poor prognostic indicator for

Jinyi Feng1, Yang Gu2, Linquan Zhou2

  • 1Department of Orthopedic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Translational Cancer Research
|February 4, 2022
PubMed
Summary

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High neural precursor cell-expressed developmentally down-regulated 9 (NEDD9) expression in osteosarcoma indicates poor prognosis. This finding suggests NEDD9 may be a potential therapeutic target for osteosarcoma treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Osteosarcoma is a primary bone malignancy with significant metastatic potential.
  • Neural precursor cell-expressed developmentally down-regulated 9 (NEDD9) has shown prognostic value in various solid tumors.
  • The role of NEDD9 in osteosarcoma prognosis remains largely uninvestigated.

Purpose of the Study:

  • To detect NEDD9 expression in osteosarcoma tissues.
  • To investigate the association between NEDD9 expression and clinicopathological features.
  • To evaluate NEDD9 as a potential prognostic biomarker for osteosarcoma.

Main Methods:

  • Immunohistochemistry was employed to assess NEDD9 expression in 45 osteosarcoma specimens.
  • Statistical analyses correlated NEDD9 levels with clinicopathological variables.
Keywords:
Neural precursor cell-expressed developmentally down-regulated 9 (NEDD9)immunohistochemistryosteosarcomaprognosis

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  • Prognostic significance was determined through univariate and multivariate analyses.

    • Main Results:

    • High NEDD9 expression was observed in 62.2% of osteosarcoma tissues.
    • NEDD9 expression significantly correlated with metastasis and Enneking stage.
    • High NEDD9 expression, metastasis, and advanced Enneking stage were independent predictors of poor overall survival.

    Conclusions:

    • Elevated NEDD9 expression is an independent indicator of poor prognosis in osteosarcoma.
    • NEDD9 represents a potential therapeutic target for improving osteosarcoma outcomes.
    • Further research into NEDD9-targeted therapies is warranted.