A review of the research progress in T-lymphocyte immunity and cervical cancer
Lina Zhang1,2, Zhilei Mao1,2, Yiqing Lai1,2
1Department of Cervical Diseases Treatment, Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou 213000, China.
Abstract:
Cervical cancer develops as a result of T-cell immune evasion by human papillomavirus (HPV). T-cell immunity requires the participation of many factors, such as antigen-presenting cells (APCs), cytokines, co-stimulatory molecules, etc. HPV vaccines are promising treatments to prevent HPV infection and cervical cancer. This article mainly provides a summary of the number and function changes of T cells during HPV infection and cervical cancer development. Studies on t-cell immunotherapy, which is expected to become a new treatment for cervical cancer after surgery, radiotherapy, and chemotherapy, are also reviewed in this article.
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