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PD-L1 for gallbladder cancer: case report.

Xiaodong Li1, Qingying Xian1, Haijiao Yan1

  • 1Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.

Translational Cancer Research
|February 4, 2022
PubMed
Summary

This case report details an advanced gallbladder cancer patient who survived 14 months with chemotherapy and immunotherapy. This offers a potential treatment strategy for biliary tract cancer.

Keywords:
Case reportPD-L1, pembrolizumabgallbladder cancer (GBC)immunotherapy

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Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Advanced biliary tract cancer (BTC) has a poor prognosis with a median survival under one year.
  • Research on gallbladder cancer (GBC) treatment, particularly second-line options, is limited.

Observation:

  • A patient presented with symptoms of advanced gallbladder cancer.
  • The patient received a combination of chemotherapy regimens (oxaliplatin, capecitabine, gemcitabine) and immunotherapy (pembrolizumab).

Findings:

  • The patient achieved a 14-month survival with no signs of disease progression.
  • The treatment regimen demonstrated a positive clinical outcome in this advanced GBC case.

Implications:

  • This case suggests a potential effective treatment template for advanced GBC.
  • The findings may contribute to improved therapeutic strategies for biliary tract cancers.