Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...

Acute Kidney Injury I: Introduction

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

From Challenge to Cure: A Look at Feline Infectious Peritonitis and Emerging Treatment Strategies and Breakthroughs.

Veterinary sciences·2025

Same author

The nucleocapsid protein of Crimean-Congo hemorrhagic fever virus interacts with eIF4A to promote the translation of viral mRNA in cells.

The Journal of biological chemistry·2025

Same author

Development of FRET-based cap-snatching endonuclease assay.

Microbiology spectrum·2025

Same author

The mRNA vaccine, a swift warhead against a moving infectious disease target.

Expert review of vaccines·2024

Same author

Modulations in the host cell proteome by the hantavirus nucleocapsid protein.

PLoS pathogens·2024

Same author

From Tick to Test: A Comprehensive Review of Tick-Borne Disease Diagnostics and Surveillance Methods in the United States.

Life (Basel, Switzerland)·2023

Search research articles

Related Experiment Video

Updated: Oct 4, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

Hantavirus Induced Kidney Disease.

Sheema Mir¹

¹College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, United States.

Frontiers in Medicine

|February 4, 2022

Summary

Hantavirus-induced hemorrhagic fever with renal syndrome (HFRS) is a growing zoonotic disease. Advances in understanding its mechanisms, epidemiology, and diagnosis are crucial for developing effective vaccines and treatments.

Area of Science:

* Virology and Immunology
* Infectious Diseases
* Nephrology

Background:

* Hantavirus-induced hemorrhagic fever with renal syndrome (HFRS) is an emerging viral zoonosis impacting global health.
* The condition is characterized by thrombocytopenia and proteinuria, with kidney injury stemming from immunopathological mechanisms.
* Endothelial cell dysfunction and compromised vascular barrier integrity are key features of HFRS pathogenesis.

Purpose of the Study:

* To review recent advancements in the understanding of hantavirus-induced HFRS.
* To discuss the epidemiology, diagnosis, and treatment strategies for HFRS.
* To highlight the role of viral and host factor interactions in therapeutic design.

Main Methods:

* Comprehensive review of current scientific literature on hantavirus-induced HFRS.

Keywords:

HFRS acute kidney injury bunyavirus hantavirus hemorrhagic fever

More Related Videos

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

Related Experiment Videos

Last Updated: Oct 4, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

* Analysis of epidemiological data linking viral species and geographical locations to disease incidence.

* Exploration of immunopathological mechanisms underlying kidney injury in HFRS.

Main Results:

* HFRS pathogenesis involves immunopathological processes affecting endothelial cells and vascular permeability.
* Epidemiology is closely tied to specific hantavirus strains and their rodent hosts' geographical distribution.
* Understanding molecular mechanisms of endothelial dysfunction requires further research.
* The potential of mRNA vaccine technology for hantavirus is a promising development.

Conclusions:

* Effective therapeutic strategies require targeting both viral replication and vascular permeability.
* Development of vaccines, potentially using mRNA platforms, and antiviral therapies is critical for future outbreak prevention.
* Further research into the molecular mechanisms of endothelial dysfunction is needed to improve HFRS management.