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Updated: Oct 4, 2025

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
Published on: November 29, 2024
Disfiguring Hidradenitis Suppurativa of the Face
Gianmarco Capasso1, Gabriella Fabbrocini1, Claudio Marasca1
1Section of Dermatology, Department of Clinical Medicine and Surgery, University Hospital Federico II of Naples, Naples, Italy.
Introduction:
Hidradenitis suppurativa (HS) is a chronic, disfiguring, and debilitating inflammatory skin condition accompanied by pain, malodorous discharge, scarring, and a scarce quality of life. Skin folds are the most frequently affected areas, while the face is rarely involved.
Case Presentation:
We herein report a case of a man in his 40s affected by a severe form of HS for 15 years. Physical examination showed massive, bridged scarring located on the cheeks, temporal area, chin, nuchae, and scalp.
Discussion:
Massive face scarring due to HS is an infrequent event and represents a further burden for patients affected by HS and a therapeutic challenge for clinicians due to the lack of codified guidelines. Novel therapies with lasers and combination therapies are emerging and may be beneficial for hypertrophic scarring in HS.
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