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Updated: Oct 4, 2025
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
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Serum Chloride Level Is Associated With Abdominal Aortic Calcification
Sheng Hu1, Tian Lan2, Silin Wang1
1Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Frontiers in Cardiovascular Medicine
|February 4, 2022
Summary
Serum chloride levels impact abdominal aortic calcification (AAC). Below 92 mmol/L, higher chloride increases AAC risk, but above this level, it appears protective.
Area of Science:
- Cardiovascular Health
- Biochemistry
- Epidemiology
Background:
- Abdominal aortic calcification (AAC) is a significant cardiovascular risk factor.
- Understanding factors influencing AAC is crucial for cardiovascular health management.
Purpose of the Study:
- To investigate the association between serum chloride levels and abdominal aortic calcification (AAC).
- To determine if serum chloride is an independent predictor of AAC.
Main Methods:
- Analysis of data from 3,018 individuals from the National Health and Nutrition Examination Survey.
- Employed stratified analysis, single factor analysis, multiple regression, and smooth curve fitting.
- Utilized R and EmpowerStats for statistical analysis, including threshold effect analysis.
Main Results:
- Serum chloride levels showed an independent relationship with the AAC-24 score.
- Fitted smooth curves revealed an inverted-U-shaped relationship.
- A cutoff value of 92 mmol/L was identified: levels below this increased AAC-24, while levels above decreased it.
Conclusions:
- Serum chloride is a risk factor for abdominal aortic calcification at levels below 92 mmol/L.
- Serum chloride levels above 92 mmol/L may offer a protective effect against abdominal aortic calcification.
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