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Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Updated: Oct 4, 2025

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Primary mediastinal chondrosarcomas: do they really exist?

Michael P Zaleski¹, Mylene Truong², Cesar A Moran¹

¹Departments of Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

Mediastinum (Hong Kong, China)

|February 4, 2022

Summary

This summary is machine-generated.

Mediastinal chondrosarcomas are rare tumors. This review clarifies diagnostic criteria, histopathology, and differential diagnoses for these challenging thoracic neoplasms.

Keywords:

Thymus chondrosarcoma imaging mediastinum mesenchymal

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Area of Science:

Oncology
Pathology
Radiology

Background:

Mediastinal chondrosarcomas are exceptionally rare neoplasms.
These tumors can occur in the anterior or posterior mediastinum.
Histopathological features resemble those of soft tissue chondrosarcomas.

Purpose of the Study:

To establish specific diagnostic criteria for mediastinal chondrosarcomas.
To detail essential histopathological assessment for accurate diagnosis.
To review current knowledge and differential diagnoses based on tumor location.

Main Methods:

Review of existing literature on mediastinal chondrosarcomas.
Emphasis on diagnostic imaging and radiological correlation.
Discussion of molecular characterization impacting tumor classification.

Main Results:

Diagnostic imaging is crucial for determining mediastinal origin.
Tumor location (anterior vs. posterior) influences differential diagnosis.
Molecular advancements are refining the classification of tumors previously considered chondrosarcomas.

Conclusions:

Accurate diagnosis requires strict radiological correlation and histopathological evaluation.
Understanding the evolving molecular landscape is key to precise tumor classification.
Specific criteria and differential diagnoses are essential for managing these rare mediastinal tumors.