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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Association between Psoriasis Disease and IFN-λ Gene Polymorphisms
Büşra Yilmaz1, Güneş Çakmak Genç1, Sevim Karakaş Çelik1
1Department of Medical Genetics, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.
Immunological Investigations
|February 4, 2022
Summary
The study found a genetic link between the IL-28B rs8099917 polymorphism and psoriasis, with a specific genotype increasing disease risk. This highlights potential genetic factors in psoriasis pathogenesis.
Area of Science:
- Immunodermatology
- Genetics
- Molecular Biology
Background:
- Psoriasis is a common chronic immune-mediated skin disease with genetic links.
- The IL-23/IL-17 axis is central to psoriasis pathogenesis.
- The role of Interferon-lambda (IFN-λ) in psoriasis is not fully understood.
Purpose of the Study:
- To investigate the association between IL-28B and IL-29 gene polymorphisms and psoriasis.
- To explore the relationship between these polymorphisms and psoriasis clinical severity.
Main Methods:
- Single-nucleotide polymorphisms (SNPs) in IL-28B (rs12979860, rs8099917) and IL-29 (rs30461) were analyzed.
- Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used.
- 140 psoriasis patients and 159 healthy controls were studied.
Main Results:
- No significant differences in genotype or allele frequencies were found for IL-28B rs12979860 and IL-29 rs30461 between patients and controls.
- The TG genotype of IL-28B rs8099917 showed a statistically significant difference between groups.
- This TG genotype was associated with a 1.9-fold increased risk of psoriasis, suggesting the G allele may contribute to disease pathogenesis.
Conclusions:
- The IL-28B rs8099917 polymorphism, specifically the TG genotype, is associated with an increased risk of psoriasis.
- The G allele of IL-28B rs8099917 may play a role in the pathogenesis of psoriasis.
- Further research is needed to elucidate the precise mechanisms of IFN-λ in psoriasis.
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