Related Experiment Video

Updated: Oct 4, 2025

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.4K

Computed tomography coronary angiography as the noninvasive in stable coronary artery disease? Long-term outcomes

Diana De Campos1, Rogério Teixeira1,2, Carolina Saleiro1

  • 1Centro Hospitalar e Universitário de Coimbra - Hospital Geral, Quinta dos Vales, São Martinho do Bispo 108, 3041-801, Coimbra, Portugal.

Future Cardiology
|February 4, 2022
PubMed

Insights

Coronary computed tomography angiography (CCTA) and functional testing (FT) showed similar outcomes for stable coronary artery disease patients. However, CCTA significantly reduced nonfatal myocardial infarction and downstream testing.

Area of Science:

  • Cardiology
  • Diagnostic Imaging
  • Evidence-Based Medicine

Background:

  • Stable coronary artery disease (CAD) diagnosis relies on various imaging modalities.
  • Coronary computed tomography angiography (CCTA) and functional testing (FT) are common diagnostic tools.
  • Comparative effectiveness of CCTA versus FT in stable CAD requires updated evidence.

Purpose of the Study:

  • To compare the clinical outcomes of CCTA versus FT in patients with stable coronary artery disease.
  • To evaluate the impact of CCTA and FT on mortality and major adverse cardiovascular events.
  • To assess the efficiency of downstream testing following CCTA or FT.

Main Methods:

  • A systematic literature search was conducted across PubMed, Embase, and Cochrane databases.
  • Randomized controlled trials (RCTs) comparing CCTA and FT were included in a random-effects meta-analysis.
  • The primary endpoint was all-cause death and nonfatal acute coronary syndromes.

Main Results:

  • Eight RCTs involving 29,579 patients were analyzed.
  • No significant difference in the primary endpoint (all-cause death and nonfatal ACS) was observed between CCTA and FT (RR = 0.97).
  • CCTA demonstrated a significant reduction in nonfatal myocardial infarction (MI) (RR = 0.59) and downstream testing (OR = 0.47) compared to FT.

Conclusions:

  • Current evidence suggests CCTA is a valuable tool for managing stable coronary artery disease.
  • CCTA improves outcomes by reducing nonfatal myocardial infarction and the need for further investigations.
  • The findings support the use of CCTA in clinical practice for stable CAD patients.

Keywords:
coronary artery diseasecoronary computed tomography angiographymyocardial infarction

More Related Videos

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

1.2K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

557

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
88
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
148
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
36
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
56
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
153
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
6.8K